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ERF

GENERAL INFORMATION

Gene name

 ERF

Gene description

 Ets2 repressor factor

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA067952
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA067952

GENE INFORMATION

Gene name

 ERF (HGNC Symbol)

Synonyms

 PE-2, PE2

Description

 Ets2 repressor factor (HGNC Symbol)

Entrez gene summary

 ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 42247572 - 42255157

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105722 (version 83.38)

Entrez gene

 2077

UniProt

 P50548 (UniProt - Evidence at protein level)

neXtProt

 NX_P50548

Antibodypedia

 ERF antibodies

PROTEIN BROWSER
ERF-001
ERF-003
ERF-006
ERF-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERF-001
ENSP00000222329
ENST00000222329
P50548 [Direct mapping]
ETS domain-containing transcription factor ERF
A0A024R0L4 [Target identity:100%; Query identity:100%]
Ets2 repressor factor, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 548 aa
58.7 kDa 		No 0
ERF-003
ENSP00000388173
ENST00000440177
P50548 [Direct mapping]
ETS domain-containing transcription factor ERF
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 473 aa
50 kDa 		No 0
ERF-006
ENSP00000469274
ENST00000593944
M0QXN0 [Direct mapping]
ETS domain-containing transcription factor ERF
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 98 aa
10.9 kDa 		No 0
ERF-007
ENSP00000468962
ENST00000598965
M0QX79 [Direct mapping]
ETS domain-containing transcription factor ERF
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   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 61 aa
7.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.