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RASA4

GENERAL INFORMATION

Gene name

 RASA4

Gene description

 RAS p21 protein activator 4

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (SH-SY5Y, U-138 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at transcript level

Protein expression
normal tissue

 Cytoplasmic expression in CNS and membranous expression in subsets of renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA043010
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043010

GENE INFORMATION

Gene name

 RASA4 (HGNC Symbol)

Synonyms

 CAPRI, GAPL, KIAA0538

Description

 RAS p21 protein activator 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 102573807 - 102616757

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000105808 (version 83.38)

Entrez gene

 10156

UniProt

 O43374 (UniProt - Evidence at transcript level)

neXtProt

 NX_O43374

Antibodypedia

 RASA4 antibodies

PROTEIN BROWSER
RASA4-001
RASA4-002
RASA4-003
RASA4-004
RASA4-010
RASA4-011
RASA4-012
RASA4-016
RASA4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASA4-001
ENSP00000262940
ENST00000262940
O43374 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0071277 [cellular response to calcium ion]
Show all
 803 aa
90.5 kDa 		No 0
RASA4-002
ENSP00000417395
ENST00000462172
E7ERK1 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 731 aa
82.3 kDa 		No 0
RASA4-003
ENSP00000420352
ENST00000461209
E7ERK1 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 731 aa
82.3 kDa 		No 0
RASA4-004
ENSP00000412876
ENST00000449970
O43374 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0071277 [cellular response to calcium ion]
Show all
 757 aa
85.4 kDa 		No 0
RASA4-010
ENSP00000430418
ENST00000522801
E5RK78 [Direct mapping]
Ras GTPase-activating protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 306 aa
35.1 kDa 		No 0
RASA4-011
ENSP00000428448
ENST00000521076
E5RID2 [Direct mapping]
Ras GTPase-activating protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 55 aa
6 kDa 		No 0
RASA4-012
ENSP00000428732
ENST00000520042
E5RGQ8 [Direct mapping]
Ras GTPase-activating protein 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 98 aa
11.1 kDa 		No 0
RASA4-016
ENSP00000428605
ENST00000521397
H0YB35 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0043087 [regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 273 aa
30.5 kDa 		No 0
RASA4-201
ENSP00000478719
ENST00000538869
A0A087WUJ9 [Direct mapping]
Ras GTPase-activating protein 4
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005737 [cytoplasm]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 160 aa
17.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.