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DNAJC2

GENERAL INFORMATION

Gene name

 DNAJC2

Gene description

 DnaJ (Hsp40) homolog, subfamily C, member 2

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA020454
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020454

GENE INFORMATION

Gene name

 DNAJC2 (HGNC Symbol)

Synonyms

 MPHOSPH11, MPP11, ZRF1, ZUO1, zuotin

Description

 DnaJ (Hsp40) homolog, subfamily C, member 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 103312474 - 103344873

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105821 (version 83.38)

Entrez gene

 27000

UniProt

 Q99543 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99543

Antibodypedia

 DNAJC2 antibodies

PROTEIN BROWSER
DNAJC2-001
DNAJC2-002
DNAJC2-003
DNAJC2-010
DNAJC2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJC2-001
ENSP00000368565
ENST00000379263
Q99543 [Direct mapping]
DnaJ homolog subfamily C member 2 DnaJ homolog subfamily C member 2, N-terminally processed
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006260 [DNA replication]
GO:0006351 [transcription, DNA-templated]
GO:0016568 [chromatin modification]
GO:0030308 [negative regulation of cell growth]
GO:0030544 [Hsp70 protein binding]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042393 [histone binding]
GO:0043130 [ubiquitin binding]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051083 ['de novo' cotranslational protein folding]
GO:1900034 [regulation of cellular response to heat]
GO:2000279 [negative regulation of DNA biosynthetic process]
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 621 aa
72 kDa 		No 0
DNAJC2-002
ENSP00000249270
ENST00000249270
Q99543 [Direct mapping]
DnaJ homolog subfamily C member 2 DnaJ homolog subfamily C member 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0016568 [chromatin modification]
GO:0030544 [Hsp70 protein binding]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0042393 [histone binding]
GO:0043130 [ubiquitin binding]
GO:0044822 [poly(A) RNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0051083 ['de novo' cotranslational protein folding]
GO:1900034 [regulation of cellular response to heat]
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 568 aa
65.9 kDa 		No 0
DNAJC2-003
ENSP00000406275
ENST00000412522
F2Z3H0 [Direct mapping]
DnaJ homolog subfamily C member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 118 aa
13.5 kDa 		No 0
DNAJC2-010
ENSP00000399058
ENST00000454277
C9IZ83 [Direct mapping]
DnaJ homolog subfamily C member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
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 188 aa
22.4 kDa 		No 0
DNAJC2-011
ENSP00000412611
ENST00000426036
H7C3L7 [Direct mapping]
DnaJ homolog subfamily C member 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 243 aa
28.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.