Expression of TFPI2 in cancer - Summary - The Human Protein Atlas

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TFPI2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TFPI2
Gene description	Tissue factor pathway inhibitor 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, U-138 MG, U-2197, U-87 MG)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA049158 , CAB010142
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable), endometrial cancer (favourable) and renal cancer (unfavourable).
Breast cancer p<0.001 Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049158	CAB010142

GENE INFORMATION
Gene name	TFPI2 (HGNC Symbol)
Synonyms	PP5, REF1, TFPI-2
Description	Tissue factor pathway inhibitor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	93885397 - 93890991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105825 (version 83.38)
Entrez gene	7980
UniProt	P48307 (UniProt - Evidence at protein level)
neXtProt	NX_P48307
Antibodypedia	TFPI2 antibodies

PROTEIN BROWSER

TFPI2-001	TFPI2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFPI2-001 ENSP00000222543 ENST00000222543	P48307 [Direct mapping] Tissue factor pathway inhibitor 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005201 [extracellular matrix structural constituent] GO:0005578 [proteinaceous extracellular matrix] GO:0005634 [nucleus] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] Show all	235 aa 26.9 kDa	Yes	0
TFPI2-003 ENSP00000416370 ENST00000451238	H7C4A3 [Direct mapping] Tissue factor pathway inhibitor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] Show all	107 aa 12 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.