Expression of PON2 in cancer - Summary - The Human Protein Atlas

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PON2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PON2
Gene description	Paraoxonase 2
Protein class	Candidate cardiovascular disease genes Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA029193 , CAB025430
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029193	CAB025430

GENE INFORMATION
Gene name	PON2
Synonyms
Description	Paraoxonase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.3
Chromosome location (bp)	95404863 - 95435329
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105854 (version 83.38)
Entrez gene	5445
UniProt	Q15165 (UniProt - Evidence at protein level)
neXtProt	NX_Q15165
Antibodypedia	PON2 antibodies

PROTEIN BROWSER

PON2-001	PON2-002	PON2-006	PON2-009	PON2-012	PON2-013	PON2-018	PON2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PON2-001 ENSP00000404622 ENST00000433091	J3QT77 [Direct mapping] Serum paraoxonase/arylesterase 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0005576 [extracellular region] GO:0008152 [metabolic process] Show all	342 aa 38 kDa	Yes	0
PON2-002 ENSP00000222572 ENST00000222572	Q15165 [Direct mapping] Serum paraoxonase/arylesterase 2 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0006979 [response to oxidative stress] GO:0009636 [response to toxic substance] GO:0019439 [aromatic compound catabolic process] GO:0042802 [identical protein binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] Show all	354 aa 39.4 kDa	Yes	0
PON2-006 ENSP00000488822 ENST00000493290		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6.2 kDa	No	0
PON2-009 ENSP00000487703 ENST00000478801		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.7 kDa	No	0
PON2-012 ENSP00000488550 ENST00000469926		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] Show all	113 aa 13.2 kDa	No	0
PON2-013 ENSP00000488826 ENST00000490778		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 8.1 kDa	No	0
PON2-018 ENSP00000488378 ENST00000633192		MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] Show all	375 aa 41.5 kDa	No	0
PON2-201 ENSP00000488838 ENST00000633531		MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004064 [arylesterase activity] Show all	354 aa 39.4 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.