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ITGB8

GENERAL INFORMATION

Gene name

 ITGB8

Gene description

 Integrin, beta 8

Protein class

 Cancer-related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a few tissues, mainly in gastrointestinal tract, squamous epithelia, heart muscle and gall bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA027796 , HPA027797
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Vagina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

 ITGB8

Synonyms

Description

 Integrin, beta 8 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p21.1

Chromosome location (bp)

 20330702 - 20415754

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105855 (version 83.38)

Entrez gene

 3696

UniProt

 P26012 (UniProt - Evidence at transcript level)

neXtProt

 NX_P26012

Antibodypedia

 ITGB8 antibodies

PROTEIN BROWSER
ITGB8-001
ITGB8-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ITGB8-001
ENSP00000222573
ENST00000222573
P26012 [Direct mapping]
Integrin beta-8
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001573 [ganglioside metabolic process]
GO:0004872 [receptor activity]
GO:0005102 [receptor binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030198 [extracellular matrix organization]
GO:0034686 [integrin alphav-beta8 complex]
GO:0051216 [cartilage development]
GO:0060674 [placenta blood vessel development]
GO:0070062 [extracellular exosome]
GO:1990430 [extracellular matrix protein binding]
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 769 aa
85.6 kDa 		Yes 1
ITGB8-005
ENSP00000441561
ENST00000537992
P26012 [Direct mapping]
Integrin beta-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008305 [integrin complex]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0030198 [extracellular matrix organization]
GO:0034686 [integrin alphav-beta8 complex]
GO:0051216 [cartilage development]
GO:0060674 [placenta blood vessel development]
GO:0070062 [extracellular exosome]
GO:1990430 [extracellular matrix protein binding]
Show all
 634 aa
71.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.