Expression of SP4 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SP4
Gene description	Sp4 transcription factor
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Additonal nuclear expression in several tissues, incluidng lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA040395 , CAB010246
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040395	CAB010246

GENE INFORMATION
Gene name	SP4 (HGNC Symbol)
Synonyms	HF1B, MGC130008, MGC130009, SPR-1
Description	Sp4 transcription factor (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	21428034 - 21514822
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105866 (version 83.38)
Entrez gene	6671
UniProt	Q02446 (UniProt - Evidence at protein level)
neXtProt	NX_Q02446
Antibodypedia	SP4 antibodies

PROTEIN BROWSER

SP4-001	SP4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SP4-001 ENSP00000222584 ENST00000222584	Q02446 [Direct mapping] Transcription factor Sp4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008016 [regulation of heart contraction] GO:0015630 [microtubule cytoskeleton] GO:0045171 [intercellular bridge] GO:0046872 [metal ion binding] Show all	784 aa 82 kDa	No	0
SP4-004 ENSP00000393623 ENST00000432066	C9JUS7 [Direct mapping] Transcription factor Sp4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	56 aa 5.7 kDa	No	0