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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PTN
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

PTN

Gene description

Pleiotrophin

Protein class

Cancer-related genes
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (AF22)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
CAB017685
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY

CAB017685

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were negative. A few cases of high grade gliomas showed strong cytoplasmic staining.

GENE INFORMATION

Gene name

PTN (HGNC Symbol)

Synonyms

HBGF8, HBNF, NEGF1

Description

Pleiotrophin (HGNC Symbol)

Entrez gene summary

Chromosome

7

Cytoband

q33

Chromosome location (bp)

137227341 - 137343865

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105894 (version 83.38)

Entrez gene

5764

UniProt

P21246 (UniProt - Evidence at protein level)

neXtProt

NX_P21246

Antibodypedia

PTN antibodies

PROTEIN BROWSER

PTN-001
PTN-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTN-001
ENSP00000341170
ENST00000348225
P21246 [Direct mapping]
Pleiotrophin
A0A024R778 [Target identity:100%; Query identity:100%]
Pleiotrophin (Heparin binding growth factor 8, neurite growth-promoting factor 1), isoform CRA_a
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   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001889 [liver development]
GO:0004864 [protein phosphatase inhibitor activity]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0007185 [transmembrane receptor protein tyrosine phosphatase signaling pathway]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007612 [learning]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0009986 [cell surface]
GO:0010811 [positive regulation of cell-substrate adhesion]
GO:0010976 [positive regulation of neuron projection development]
GO:0014823 [response to activity]
GO:0016020 [membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0021510 [spinal cord development]
GO:0021549 [cerebellum development]
GO:0021794 [thalamus development]
GO:0030282 [bone mineralization]
GO:0030324 [lung development]
GO:0030336 [negative regulation of cell migration]
GO:0030902 [hindbrain development]
GO:0031594 [neuromuscular junction]
GO:0032355 [response to estradiol]
GO:0032570 [response to progesterone]
GO:0034644 [cellular response to UV]
GO:0035373 [chondroitin sulfate proteoglycan binding]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038085 [vascular endothelial growth factor binding]
GO:0042493 [response to drug]
GO:0043065 [positive regulation of apoptotic process]
GO:0043086 [negative regulation of catalytic activity]
GO:0043394 [proteoglycan binding]
GO:0044849 [estrous cycle]
GO:0045446 [endothelial cell differentiation]
GO:0045837 [negative regulation of membrane potential]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0060041 [retina development in camera-type eye]
GO:0060221 [retinal rod cell differentiation]
GO:0060253 [negative regulation of glial cell proliferation]
GO:0060291 [long-term synaptic potentiation]
GO:0071305 [cellular response to vitamin D]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0072201 [negative regulation of mesenchymal cell proliferation]
GO:1904373 [response to kainic acid]
GO:1904389 [rod bipolar cell differentiation]
GO:1904391 [response to ciliary neurotrophic factor]
GO:1904395 [positive regulation of skeletal muscle acetylcholine-gated channel clustering]
GO:1904397 [negative regulation of neuromuscular junction development]
GO:1904399 [heparan sulfate binding]
GO:1990089 [response to nerve growth factor]
GO:2000347 [positive regulation of hepatocyte proliferation]
Show all
168 aa
18.9 kDa
Yes 0
PTN-002
ENSP00000376798
ENST00000393083
C9JR52 [Direct mapping]
Pleiotrophin
Show all
   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008083 [growth factor activity]
Show all
166 aa
18.9 kDa
Yes 0

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