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Rare cases of gliomas, melanoma, colorectal, prostate, urothelial, renal, pancreatic and liver cancers displayed moderate cytoplasmic and membranous positivity. Remaining cancer tissues were weakly stained or negative.
Several cases of melanomas and thyroid cancers along with a few cases of gliomas, breast, prostate, testis, urothelial and renal cancers displayed moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]