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ATP6V0A4

GENERAL INFORMATION

Gene name

 ATP6V0A4

Gene description

 ATPase, H+ transporting, lysosomal V0 subunit a4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Cell line enriched (SK-BR-3)
HPA (normal tissue):Group enriched (kidney, salivary gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of cells in renal tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018029 , HPA064555
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018029
HPA064555

GENE INFORMATION

Gene name

 ATP6V0A4 (HGNC Symbol)

Synonyms

 a4, ATP6N1B, ATP6N2, RDRTA2, RTA1C, RTADR, Stv1, Vph1, VPP2

Description

 ATPase, H+ transporting, lysosomal V0 subunit a4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q34

Chromosome location (bp)

 138706295 - 138799560

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105929 (version 83.38)

Entrez gene

 50617

UniProt

 Q9HBG4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBG4

Antibodypedia

 ATP6V0A4 antibodies

PROTEIN BROWSER
ATP6V0A4-001
ATP6V0A4-002
ATP6V0A4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP6V0A4-001
ENSP00000308122
ENST00000310018
Q9HBG4 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 4
A0A024R791 [Target identity:100%; Query identity:100%]
V-type proton ATPase subunit a
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Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0006879 [cellular iron ion homeostasis]
GO:0006885 [regulation of pH]
GO:0007035 [vacuolar acidification]
GO:0007588 [excretion]
GO:0007605 [sensory perception of sound]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0045177 [apical part of cell]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
Show all
 840 aa
96.4 kDa 		No 8
ATP6V0A4-002
ENSP00000253856
ENST00000353492
Q9HBG4 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 4
A0A024R791 [Target identity:100%; Query identity:100%]
V-type proton ATPase subunit a
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006885 [regulation of pH]
GO:0007035 [vacuolar acidification]
GO:0007588 [excretion]
GO:0007605 [sensory perception of sound]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0045177 [apical part of cell]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
Show all
 840 aa
96.4 kDa 		No 8
ATP6V0A4-201
ENSP00000376774
ENST00000393054
Q9HBG4 [Direct mapping]
V-type proton ATPase 116 kDa subunit a isoform 4
A0A024R791 [Target identity:100%; Query identity:100%]
V-type proton ATPase subunit a
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain]
GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006879 [cellular iron ion homeostasis]
GO:0006885 [regulation of pH]
GO:0007035 [vacuolar acidification]
GO:0007588 [excretion]
GO:0007605 [sensory perception of sound]
GO:0008286 [insulin receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015986 [ATP synthesis coupled proton transport]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0016471 [vacuolar proton-transporting V-type ATPase complex]
GO:0030670 [phagocytic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0033179 [proton-transporting V-type ATPase, V0 domain]
GO:0033572 [transferrin transport]
GO:0034220 [ion transmembrane transport]
GO:0045177 [apical part of cell]
GO:0046961 [proton-transporting ATPase activity, rotational mechanism]
GO:0051117 [ATPase binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly]
GO:0090382 [phagosome maturation]
Show all
 840 aa
96.4 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.