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OGDH

GENERAL INFORMATION

Gene name

 OGDH

Gene description

 Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Protein class

 Citric acid cycle related proteins
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA019514 , HPA020347
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA019514
HPA020347

GENE INFORMATION

Gene name

 OGDH (HGNC Symbol)

Synonyms

 E1k

Description

 Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (HGNC Symbol)

Entrez gene summary

 This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44606572 - 44709066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105953 (version 83.38)

Entrez gene

 4967

UniProt

 Q02218 (UniProt - Evidence at protein level)

neXtProt

 NX_Q02218

Antibodypedia

 OGDH antibodies

PROTEIN BROWSER
OGDH-001
OGDH-002
OGDH-003
OGDH-005
OGDH-006
OGDH-007
OGDH-008
OGDH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OGDH-001
ENSP00000222673
ENST00000222673
Q02218 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006096 [glycolytic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006104 [succinyl-CoA metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006734 [NADH metabolic process]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0021695 [cerebellar cortex development]
GO:0021756 [striatum development]
GO:0021766 [hippocampus development]
GO:0021794 [thalamus development]
GO:0021860 [pyramidal neuron development]
GO:0022028 [tangential migration from the subventricular zone to the olfactory bulb]
GO:0030976 [thiamine pyrophosphate binding]
GO:0031072 [heat shock protein binding]
GO:0031966 [mitochondrial membrane]
GO:0034602 [oxoglutarate dehydrogenase (NAD+) activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055114 [oxidation-reduction process]
GO:0061034 [olfactory bulb mitral cell layer development]
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 1023 aa
115.9 kDa 		No 0
OGDH-002
ENSP00000392878
ENST00000449767
Q02218 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006096 [glycolytic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0006554 [lysine catabolic process]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0031966 [mitochondrial membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 1019 aa
115.5 kDa 		No 0
OGDH-003
ENSP00000388183
ENST00000447398
E9PDF2 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0055114 [oxidation-reduction process]
Show all
 1034 aa
117.2 kDa 		No 0
OGDH-005
ENSP00000398576
ENST00000439616
E9PFG7 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0055114 [oxidation-reduction process]
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 873 aa
99 kDa 		No 0
OGDH-006
ENSP00000414662
ENST00000444676
E9PCR7 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0055114 [oxidation-reduction process]
Show all
 1038 aa
117.7 kDa 		No 0
OGDH-007
ENSP00000388084
ENST00000443864
Q02218 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006096 [glycolytic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0006554 [lysine catabolic process]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0031966 [mitochondrial membrane]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0046872 [metal ion binding]
Show all
 427 aa
48.2 kDa 		No 0
OGDH-008
ENSP00000411830
ENST00000419661
C9J4G7 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0005739 [mitochondrion]
GO:0006099 [tricarboxylic acid cycle]
GO:0030976 [thiamine pyrophosphate binding]
GO:0045252 [oxoglutarate dehydrogenase complex]
Show all
 211 aa
23.2 kDa 		No 0
OGDH-201
ENSP00000486854
ENST00000631326
A0A0D9SFS3 [Direct mapping]
2-oxoglutarate dehydrogenase, mitochondrial
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004591 [oxoglutarate dehydrogenase (succinyl-transferring) activity]
GO:0006099 [tricarboxylic acid cycle]
GO:0008152 [metabolic process]
GO:0016624 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor]
GO:0030976 [thiamine pyrophosphate binding]
GO:0045252 [oxoglutarate dehydrogenase complex]
GO:0055114 [oxidation-reduction process]
Show all
 1001 aa
113.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.