Expression of NPVF in cancer - Summary - The Human Protein Atlas

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NPVF

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NPVF
Gene description	Neuropeptide VF precursor
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in nerve fibers in retina and hypothalamus.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA041733
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041733

GENE INFORMATION
Gene name	NPVF (HGNC Symbol)
Synonyms	C7orf9, RFRP
Description	Neuropeptide VF precursor (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	25224570 - 25228486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105954 (version 83.38)
Entrez gene	64111
UniProt	Q9HCQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCQ7
Antibodypedia	NPVF antibodies

PROTEIN BROWSER

NPVF-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NPVF-001 ENSP00000222674 ENST00000222674	Q9HCQ7 [Direct mapping] Pro-FMRFamide-related neuropeptide VF Neuropeptide NPSF Neuropeptide RFRP-1 Neuropeptide RFRP-2 Neuropeptide NPVF Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0007218 [neuropeptide signaling pathway] GO:0032277 [negative regulation of gonadotropin secretion] Show all	196 aa 22.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.