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Several malignant melanomas, squamous and basal cell carcinomas, urothelial, pancreatic, thyroid and liver cancers along with a few ovarian and colorectal cancers displayed moderate to strong cytoplasmic staining with additional membranous positivity in several cases. Remaining cancer tissues were negative.
Malignant melanomas, skin, renal, pancreatic, thyroid and liver cancers as well as head and neck cancer displayed moderate to strong cytoplasmic staining. Remaining malignant cells were generally weakly stained or negative.
GENE INFORMATION
Gene name
CAV2 (HGNC Symbol)
Synonyms
CAV
Description
Caveolin 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]