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Gene name

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In atlas

Reliability

Reliability

Reliability

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Validation

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Validation

Method

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Searches

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Expression

Tissue

Specificity

Cell line

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Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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CAV1
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CAV1

Gene description

Caveolin 1, caveolae protein, 22kDa

Protein class

Cancer-related genes
Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Distinct expression in endothelial cells, adipocytes, pneumocytes and basal cells of squamous epithelia.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA049326 , CAB003791
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CAV1 (HGNC Symbol)

Synonyms

CAV

Description

Caveolin 1, caveolae protein, 22kDa (HGNC Symbol)

Entrez gene summary

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Chromosome

7

Cytoband

q31.2

Chromosome location (bp)

116524785 - 116561184

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105974 (version 83.38)

Entrez gene

857

UniProt

Q03135 (UniProt - Evidence at protein level)

neXtProt

NX_Q03135

Antibodypedia

CAV1 antibodies

PROTEIN BROWSER

CAV1-001
CAV1-003
CAV1-004
CAV1-006
CAV1-007
CAV1-008
CAV1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAV1-001
ENSP00000339191
ENST00000341049
Q03135 [Direct mapping]
Caveolin-1
Q2TNI1 [Target identity:100%; Query identity:100%]
Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000149 [SNARE binding]
GO:0000165 [MAPK cascade]
GO:0000188 [inactivation of MAPK activity]
GO:0001179 [RNA polymerase I transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0001960 [negative regulation of cytokine-mediated signaling pathway]
GO:0002026 [regulation of the force of heart contraction]
GO:0002080 [acrosomal membrane]
GO:0002931 [response to ischemia]
GO:0003057 [regulation of the force of heart contraction by chemical signal]
GO:0005102 [receptor binding]
GO:0005113 [patched binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005768 [endosome]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0005938 [cell cortex]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0007584 [response to nutrient]
GO:0007595 [lactation]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008285 [negative regulation of cell proliferation]
GO:0009267 [cellular response to starvation]
GO:0009612 [response to mechanical stimulus]
GO:0009617 [response to bacterium]
GO:0009925 [basal plasma membrane]
GO:0009967 [positive regulation of signal transduction]
GO:0009968 [negative regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010332 [response to gamma radiation]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0010608 [posttranscriptional regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010656 [negative regulation of muscle cell apoptotic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0019905 [syntaxin binding]
GO:0019915 [lipid storage]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030674 [protein binding, bridging]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031100 [organ regeneration]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032947 [protein complex scaffold]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033344 [cholesterol efflux]
GO:0033484 [nitric oxide homeostasis]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042060 [wound healing]
GO:0042310 [vasoconstriction]
GO:0042493 [response to drug]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045807 [positive regulation of endocytosis]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046209 [nitric oxide metabolic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046785 [microtubule polymerization]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0050900 [leukocyte migration]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051001 [negative regulation of nitric-oxide synthase activity]
GO:0051117 [ATPase binding]
GO:0051259 [protein oligomerization]
GO:0051260 [protein homooligomerization]
GO:0051384 [response to glucocorticoid]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0060546 [negative regulation of necroptotic process]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070836 [caveola assembly]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0090398 [cellular senescence]
GO:0097190 [apoptotic signaling pathway]
GO:0097371 [MDM2/MDM4 family protein binding]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
GO:2001258 [negative regulation of cation channel activity]
Show all
178 aa
20.5 kDa
No 1
CAV1-003
ENSP00000377110
ENST00000393467
Q03135 [Direct mapping]
Caveolin-1
A0A024R757 [Target identity:100%; Query identity:100%]
Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000188 [inactivation of MAPK activity]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005113 [patched binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032947 [protein complex scaffold]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046209 [nitric oxide metabolic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0050900 [leukocyte migration]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
147 aa
17 kDa
No 1
CAV1-004
ENSP00000377111
ENST00000393468
Q03135 [Direct mapping]
Caveolin-1
A0A024R757 [Target identity:100%; Query identity:100%]
Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000188 [inactivation of MAPK activity]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005113 [patched binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032947 [protein complex scaffold]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046209 [nitric oxide metabolic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0050900 [leukocyte migration]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
147 aa
17 kDa
No 1
CAV1-006
ENSP00000377113
ENST00000393470
E9PCT5 [Direct mapping]
Caveolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005901 [caveola]
GO:0016021 [integral component of membrane]
GO:0070836 [caveola assembly]
Show all
167 aa
19.2 kDa
No 1
CAV1-007
ENSP00000389033
ENST00000456473
C9JKI3 [Direct mapping]
Caveolin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005901 [caveola]
GO:0016021 [integral component of membrane]
GO:0070836 [caveola assembly]
Show all
138 aa
15.9 kDa
No 1
CAV1-008
ENSP00000384348
ENST00000405348
Q03135 [Direct mapping]
Caveolin-1
A0A024R757 [Target identity:100%; Query identity:100%]
Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000188 [inactivation of MAPK activity]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005113 [patched binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032947 [protein complex scaffold]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046209 [nitric oxide metabolic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0050900 [leukocyte migration]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
147 aa
17 kDa
No 1
CAV1-201
ENSP00000479447
ENST00000614113
Q03135 [Direct mapping]
Caveolin-1
A0A024R757 [Target identity:100%; Query identity:100%]
Caveolin
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000139 [Golgi membrane]
GO:0000188 [inactivation of MAPK activity]
GO:0001570 [vasculogenesis]
GO:0001666 [response to hypoxia]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0005102 [receptor binding]
GO:0005113 [patched binding]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006641 [triglyceride metabolic process]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006940 [regulation of smooth muscle contraction]
GO:0007519 [skeletal muscle tissue development]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0009267 [cellular response to starvation]
GO:0009617 [response to bacterium]
GO:0010524 [positive regulation of calcium ion transport into cytosol]
GO:0015485 [cholesterol binding]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0016504 [peptidase activator activity]
GO:0019065 [receptor-mediated endocytosis of virus by host cell]
GO:0019217 [regulation of fatty acid metabolic process]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019915 [lipid storage]
GO:0030193 [regulation of blood coagulation]
GO:0030301 [cholesterol transport]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030666 [endocytic vesicle membrane]
GO:0030857 [negative regulation of epithelial cell differentiation]
GO:0030879 [mammary gland development]
GO:0031295 [T cell costimulation]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031410 [cytoplasmic vesicle]
GO:0031901 [early endosome membrane]
GO:0032091 [negative regulation of protein binding]
GO:0032092 [positive regulation of protein binding]
GO:0032507 [maintenance of protein location in cell]
GO:0032570 [response to progesterone]
GO:0032947 [protein complex scaffold]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033484 [nitric oxide homeostasis]
GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex]
GO:0034141 [positive regulation of toll-like receptor 3 signaling pathway]
GO:0042632 [cholesterol homeostasis]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0044860 [protein localization to plasma membrane raft]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045121 [membrane raft]
GO:0045907 [positive regulation of vasoconstriction]
GO:0046209 [nitric oxide metabolic process]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048550 [negative regulation of pinocytosis]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0050900 [leukocyte migration]
GO:0050998 [nitric-oxide synthase binding]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0051899 [membrane depolarization]
GO:0052547 [regulation of peptidase activity]
GO:0055074 [calcium ion homeostasis]
GO:0060056 [mammary gland involution]
GO:0060355 [positive regulation of cell adhesion molecule production]
GO:0061099 [negative regulation of protein tyrosine kinase activity]
GO:0070320 [inward rectifier potassium channel inhibitor activity]
GO:0070836 [caveola assembly]
GO:0071360 [cellular response to exogenous dsRNA]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071455 [cellular response to hyperoxia]
GO:0072584 [caveolin-mediated endocytosis]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097190 [apoptotic signaling pathway]
GO:0098903 [regulation of membrane repolarization during action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
GO:1900027 [regulation of ruffle assembly]
GO:1900085 [negative regulation of peptidyl-tyrosine autophosphorylation]
GO:1901380 [negative regulation of potassium ion transmembrane transport]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901979 [regulation of inward rectifier potassium channel activity]
GO:1903071 [positive regulation of ER-associated ubiquitin-dependent protein catabolic process]
GO:1903361 [protein localization to basolateral plasma membrane]
GO:1903598 [positive regulation of gap junction assembly]
GO:2000286 [receptor internalization involved in canonical Wnt signaling pathway]
GO:2000535 [regulation of entry of bacterium into host cell]
GO:2000811 [negative regulation of anoikis]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
147 aa
17 kDa
No 1

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