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LFNG

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GENERAL INFORMATION

Gene name

 LFNG

Gene description

 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-2 OS, RH-30)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2 OS, RH-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 LFNG (HGNC Symbol)

Synonyms

 SCDO3

Description

 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (HGNC Symbol)

Entrez gene summary

 This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 7

Cytoband

 p22.3

Chromosome location (bp)

 2512529 - 2529177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106003 (version 83.38)

Entrez gene

 3955

UniProt

 Q8NES3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NES3

Antibodypedia

 LFNG antibodies

PROTEIN BROWSER
LFNG-001
LFNG-002
LFNG-003
LFNG-004
LFNG-201
LFNG-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LFNG-001
ENSP00000222725
ENST00000222725
Q8NES3 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001756 [somitogenesis]
GO:0002315 [marginal zone B cell differentiation]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0007143 [female meiotic division]
GO:0007219 [Notch signaling pathway]
GO:0007386 [compartment pattern specification]
GO:0007389 [pattern specification process]
GO:0008152 [metabolic process]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0014807 [regulation of somitogenesis]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030173 [integral component of Golgi membrane]
GO:0030217 [T cell differentiation]
GO:0032092 [positive regulation of protein binding]
GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046872 [metal ion binding]
GO:1902367 [negative regulation of Notch signaling pathway involved in somitogenesis]
GO:1903561 [extracellular vesicle]
Show all
 379 aa
41.8 kDa 		Yes 0
LFNG-002
ENSP00000352579
ENST00000359574
Q8NES3 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0002315 [marginal zone B cell differentiation]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0007219 [Notch signaling pathway]
GO:0007389 [pattern specification process]
GO:0008152 [metabolic process]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0014807 [regulation of somitogenesis]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030173 [integral component of Golgi membrane]
GO:0030217 [T cell differentiation]
GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity]
GO:0046872 [metal ion binding]
GO:1902367 [negative regulation of Notch signaling pathway involved in somitogenesis]
GO:1903561 [extracellular vesicle]
Show all
 361 aa
39.6 kDa 		Yes 0
LFNG-003
ENSP00000385764
ENST00000402506
Q8NES3 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0002315 [marginal zone B cell differentiation]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0007219 [Notch signaling pathway]
GO:0008152 [metabolic process]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0014807 [regulation of somitogenesis]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030173 [integral component of Golgi membrane]
GO:0030217 [T cell differentiation]
GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity]
GO:0046872 [metal ion binding]
GO:1902367 [negative regulation of Notch signaling pathway involved in somitogenesis]
GO:1903561 [extracellular vesicle]
Show all
 308 aa
35.3 kDa 		No 0
LFNG-004
ENSP00000384786
ENST00000402045
Q8NES3 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0002315 [marginal zone B cell differentiation]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0007219 [Notch signaling pathway]
GO:0008152 [metabolic process]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0014807 [regulation of somitogenesis]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030173 [integral component of Golgi membrane]
GO:0030217 [T cell differentiation]
GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity]
GO:0046872 [metal ion binding]
GO:1902367 [negative regulation of Notch signaling pathway involved in somitogenesis]
GO:1903561 [extracellular vesicle]
Show all
 250 aa
28.2 kDa 		No 0
LFNG-201
ENSP00000343095
ENST00000338732
Q8NES3 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001756 [somitogenesis]
GO:0002315 [marginal zone B cell differentiation]
GO:0003674 [molecular_function]
GO:0005576 [extracellular region]
GO:0007219 [Notch signaling pathway]
GO:0008152 [metabolic process]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009887 [organ morphogenesis]
GO:0014807 [regulation of somitogenesis]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030173 [integral component of Golgi membrane]
GO:0030217 [T cell differentiation]
GO:0033829 [O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity]
GO:0046872 [metal ion binding]
GO:1902367 [negative regulation of Notch signaling pathway involved in somitogenesis]
GO:1903561 [extracellular vesicle]
Show all
 250 aa
28.2 kDa 		No 0
LFNG-202
ENSP00000483986
ENST00000614382
A0A087X191 [Direct mapping]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
Show all
 248 aa
28 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.