Cell atlas - BRAT1 - The Human Protein Atlas

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BRAT1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BRAT1
Gene description	BRCA1-associated ATM activator 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA076508
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA076508	PC-3	Nucleoplasm
	HPA076508	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	BRAT1 (HGNC Symbol)
Synonyms	BAAT1, C7orf27, MGC22916
Description	BRCA1-associated ATM activator 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]
Chromosome	7
Cytoband	p22.3
Chromosome location (bp)	2537877 - 2555727
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106009 (version 83.38)
Entrez gene	221927
UniProt	Q6PJG6 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PJG6
Antibodypedia	BRAT1 antibodies

PROTEIN BROWSER

BRAT1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRAT1-001 ENSP00000339637 ENST00000340611	Q6PJG6 [Direct mapping] BRCA1-associated ATM activator 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006006 [glucose metabolic process] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008283 [cell proliferation] GO:0010212 [response to ionizing radiation] GO:0016020 [membrane] GO:0016049 [cell growth] GO:0016477 [cell migration] GO:0051646 [mitochondrion localization] Show all	821 aa 88.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.