Cell atlas - HIBADH - The Human Protein Atlas

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HIBADH

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	HIBADH
Gene description	3-hydroxyisobutyrate dehydrogenase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	HIBADH (HGNC Symbol)
Synonyms	NS5ATP1
Description	3-hydroxyisobutyrate dehydrogenase (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
Chromosome	7
Cytoband	p15.2
Chromosome location (bp)	27525442 - 27662995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106049 (version 83.38)
Entrez gene	11112
UniProt	P31937 (UniProt - Evidence at protein level)
neXtProt	NX_P31937
Antibodypedia	HIBADH antibodies

PROTEIN BROWSER

HIBADH-001	HIBADH-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIBADH-001 ENSP00000265395 ENST00000265395	P31937 [Direct mapping] 3-hydroxyisobutyrate dehydrogenase, mitochondrial A0A024RA75 [Target identity:100%; Query identity:100%] 3-hydroxyisobutyrate dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006574 [valine catabolic process] GO:0008442 [3-hydroxyisobutyrate dehydrogenase activity] GO:0009083 [branched-chain amino acid catabolic process] GO:0016491 [oxidoreductase activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	336 aa 35.3 kDa	No	0
HIBADH-005 ENSP00000390205 ENST00000425715	H7BZL2 [Direct mapping] 3-hydroxyisobutyrate dehydrogenase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0008442 [3-hydroxyisobutyrate dehydrogenase activity] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	206 aa 21.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.