Expression of CPVL in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CPVL
Gene description	Carboxypeptidase, vitellogenic-like
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BEWO, RPTEC TERT1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in macrophages, thyroid glandular cells, cardiac myocytes and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA045715 , HPA056466 , CAB003697
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and urothelial cancer (unfavourable).
Endometrial cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA045715	HPA056466	CAB003697

GENE INFORMATION
Gene name	CPVL
Synonyms
Description	Carboxypeptidase, vitellogenic-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a carboxypeptidase and bears strong sequence similarity to serine carboxypeptidases. Carboxypeptidases are a large class of proteases that act to cleave a single amino acid from the carboxy termini of proteins or peptides. The exact function of this protein, however, has not been determined. At least two alternatively spliced transcripts which encode the same protein have been observed. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	28995231 - 29195451
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106066 (version 83.38)
Entrez gene	54504
UniProt	Q9H3G5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3G5
Antibodypedia	CPVL antibodies

PROTEIN BROWSER

CPVL-001	CPVL-002	CPVL-003	CPVL-004	CPVL-005	CPVL-006	CPVL-007	CPVL-009	CPVL-010	CPVL-011	CPVL-012	CPVL-201	CPVL-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CPVL-001 ENSP00000265394 ENST00000265394	Q9H3G5 [Direct mapping] Probable serine carboxypeptidase CPVL A0A024RA40 [Target identity:100%; Query identity:100%] Carboxypeptidase, vitellogenic-like, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0070062 [extracellular exosome] Show all	476 aa 54.2 kDa	Yes	0
CPVL-002 ENSP00000379572 ENST00000396276	Q9H3G5 [Direct mapping] Probable serine carboxypeptidase CPVL A0A024RA40 [Target identity:100%; Query identity:100%] Carboxypeptidase, vitellogenic-like, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0070062 [extracellular exosome] Show all	476 aa 54.2 kDa	Yes	0
CPVL-003 ENSP00000395690 ENST00000447426	C9JI22 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	142 aa 16.1 kDa	No	0
CPVL-004 ENSP00000409036 ENST00000448959	C9JLV0 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	244 aa 27.8 kDa	No	0
CPVL-005 ENSP00000417015 ENST00000458405	C9J6L4 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	100 aa 11.4 kDa	No	0
CPVL-006 ENSP00000403580 ENST00000455893	H7C218 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	141 aa 16.5 kDa	No	0
CPVL-007 ENSP00000397327 ENST00000432534	H7C0X5 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	180 aa 21.1 kDa	No	0
CPVL-009 ENSP00000387164 ENST00000409850	Q9H3G5 [Direct mapping] Probable serine carboxypeptidase CPVL A0A024RA40 [Target identity:100%; Query identity:100%] Carboxypeptidase, vitellogenic-like, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] GO:0070062 [extracellular exosome] Show all	476 aa 54.2 kDa	Yes	0
CPVL-010 ENSP00000412857 ENST00000455544	C9JVI2 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.6 kDa	Yes	0
CPVL-011 ENSP00000416555 ENST00000437527		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
CPVL-012 ENSP00000413287 ENST00000449801	C9JZ94 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 5.6 kDa	Yes	0
CPVL-201 ENSP00000479581 ENST00000612187	A0A087WVP6 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	232 aa 26.8 kDa	No	0
CPVL-202 ENSP00000481092 ENST00000614864	A0A087WXJ9 [Direct mapping] Probable serine carboxypeptidase CPVL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004185 [serine-type carboxypeptidase activity] GO:0006508 [proteolysis] Show all	230 aa 26.6 kDa	No	0