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GRB10

GENERAL INFORMATION

Gene name

 GRB10

Gene description

 Growth factor receptor-bound protein 10

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA027502 , CAB019423
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA027502
CAB019423

GENE INFORMATION

Gene name

 GRB10

Synonyms

Description

 Growth factor receptor-bound protein 10 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

Chromosome

 7

Cytoband

 p12.1

Chromosome location (bp)

 50590063 - 50793462

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106070 (version 83.38)

Entrez gene

 2887

UniProt

 Q13322 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13322

Antibodypedia

 GRB10 antibodies

PROTEIN BROWSER
«
GRB10-001
GRB10-002
GRB10-003
GRB10-004
GRB10-005
GRB10-006
GRB10-007
GRB10-014
GRB10-015
GRB10-201
GRB10-202
GRB10-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRB10-001
ENSP00000385544
ENST00000403097
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 588 aa
66.5 kDa 		No 0
GRB10-002
ENSP00000385748
ENST00000402497
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-003
ENSP00000385770
ENST00000401949
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 594 aa
67.2 kDa 		No 0
GRB10-004
ENSP00000385366
ENST00000406641
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-005
ENSP00000349818
ENST00000357271
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 548 aa
62 kDa 		No 0
GRB10-006
ENSP00000385189
ENST00000402578
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-007
ENSP00000385046
ENST00000407526
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-014
ENSP00000413023
ENST00000439044
C9JTW6 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.4 kDa 		No 0
GRB10-015
ENSP00000410920
ENST00000428711
H7C3B9 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007165 [signal transduction]
Show all
 108 aa
12.7 kDa 		No 0
GRB10-201
ENSP00000338543
ENST00000335866
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-202
ENSP00000381790
ENST00000398810
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
Show all
 536 aa
60.8 kDa 		No 0
GRB10-203
ENSP00000381793
ENST00000398812
Q13322 [Direct mapping]
Growth factor receptor-bound protein 10
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032868 [response to insulin]
GO:0042326 [negative regulation of phosphorylation]
GO:0042327 [positive regulation of phosphorylation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0048009 [insulin-like growth factor receptor signaling pathway]
Show all
 594 aa
67.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.