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FKBP14

GENERAL INFORMATION

Gene name

 FKBP14

Gene description

 FK506 binding protein 14, 22 kDa

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 2 antibodies.
HPA013329 , HPA026829
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable), urothelial cancer (unfavourable), stomach cancer (unfavourable) and liver cancer (unfavourable).
Breast cancer p<0.001
Urothelial cancer p<0.001
Stomach cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA013329
HPA026829

GENE INFORMATION

Gene name

 FKBP14 (HGNC Symbol)

Synonyms

 FKBP22, FLJ20731

Description

 FK506 binding protein 14, 22 kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]

Chromosome

 7

Cytoband

 p14.3

Chromosome location (bp)

 30010587 - 30026684

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106080 (version 83.38)

Entrez gene

 55033

UniProt

 Q9NWM8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NWM8

Antibodypedia

 FKBP14 antibodies

PROTEIN BROWSER
FKBP14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP14-001
ENSP00000222803
ENST00000222803
Q9NWM8 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP14
A0A090N7V8 [Target identity:100%; Query identity:100%]
FK506 binding protein 14, 22 kDa
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Enzymes
   ENZYME proteins
   Isomerase
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005509 [calcium ion binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0061077 [chaperone-mediated protein folding]
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 211 aa
24.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.