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STX1A

GENERAL INFORMATION

Gene name

 STX1A

Gene description

 Syntaxin 1A (brain)

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in CNS, peripheral nerves in several tissues and endocrine cells in gastrointestinal tract and pancreas.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA069176 , CAB008372
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and cervical cancer (unfavourable).
Endometrial cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY
HPA069176
CAB008372

GENE INFORMATION

Gene name

 STX1A (HGNC Symbol)

Synonyms

 HPC-1, p35-1, STX1

Description

 Syntaxin 1A (brain) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73699206 - 73719672

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106089 (version 83.38)

Entrez gene

 6804

UniProt

 Q16623 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16623

Antibodypedia

 STX1A antibodies

PROTEIN BROWSER
STX1A-001
STX1A-002
STX1A-003
STX1A-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STX1A-001
ENSP00000222812
ENST00000222812
Q16623 [Direct mapping]
Syntaxin-1A
Q75ME0 [Target identity:100%; Query identity:100%]
Putative uncharacterized protein STX1A; STX1A protein; Syntaxin 1A (Brain), isoform CRA_e; Syntaxin 1A isoform A; cDNA, FLJ94630, Homo sapiens syntaxin 1A (brain) (STX1A), mRNA
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000149 [SNARE binding]
GO:0001948 [glycoprotein binding]
GO:0001956 [positive regulation of neurotransmitter secretion]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009629 [response to gravity]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0010807 [regulation of synaptic vesicle priming]
GO:0012505 [endomembrane system]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0017157 [regulation of exocytosis]
GO:0019855 [calcium channel inhibitor activity]
GO:0019869 [chloride channel inhibitor activity]
GO:0019900 [kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0030141 [secretory granule]
GO:0030672 [synaptic vesicle membrane]
GO:0030674 [protein binding, bridging]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0032028 [myosin head/neck binding]
GO:0032940 [secretion by cell]
GO:0033605 [positive regulation of catecholamine secretion]
GO:0042641 [actomyosin]
GO:0043005 [neuron projection]
GO:0043008 [ATP-dependent protein binding]
GO:0043229 [intracellular organelle]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044325 [ion channel binding]
GO:0045921 [positive regulation of exocytosis]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048278 [vesicle docking]
GO:0048306 [calcium-dependent protein binding]
GO:0050796 [regulation of insulin secretion]
GO:0070032 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex]
GO:0070033 [synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex]
GO:0070044 [synaptobrevin 2-SNAP-25-syntaxin-1a complex]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
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 288 aa
33 kDa 		No 1
STX1A-002
ENSP00000378585
ENST00000395156
Q16623 [Direct mapping]
Syntaxin-1A
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0008076 [voltage-gated potassium channel complex]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0012505 [endomembrane system]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0019869 [chloride channel inhibitor activity]
GO:0019900 [kinase binding]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0032940 [secretion by cell]
GO:0033605 [positive regulation of catecholamine secretion]
GO:0043005 [neuron projection]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045956 [positive regulation of calcium ion-dependent exocytosis]
GO:0048278 [vesicle docking]
GO:0050796 [regulation of insulin secretion]
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 251 aa
29 kDa 		No 0
STX1A-003
ENSP00000378584
ENST00000395155
A0A0C4DFZ1 [Direct mapping]
Syntaxin-1A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0017157 [regulation of exocytosis]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
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 260 aa
29.6 kDa 		No 0
STX1A-010
ENSP00000378583
ENST00000395154
A8MZ54 [Direct mapping]
Syntaxin-1A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006886 [intracellular protein transport]
GO:0006887 [exocytosis]
GO:0008021 [synaptic vesicle]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0017022 [myosin binding]
GO:0017157 [regulation of exocytosis]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0048278 [vesicle docking]
Show all
 280 aa
31.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.