Cell atlas - GARS - The Human Protein Atlas

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GARS

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	GARS
Gene description	Glycyl-tRNA synthetase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA017896
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017896	A-431	Cytosol
	HPA017896	U-2 OS	Cytosol
	HPA017896	U-251 MG	Cytosol

MOUSE CELLS

Main location

Cytosol

Mouse gene

ENSMUSG00000029777 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA017896	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	GARS (HGNC Symbol)
Synonyms	CMT2D, DSMAV, GlyRS, SMAD1
Description	Glycyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded enzyme is an (alpha)2 dimer which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	7
Cytoband	p14.3
Chromosome location (bp)	30594681 - 30634033
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106105 (version 83.38)
Entrez gene	2617
UniProt	P41250 (UniProt - Evidence at protein level)
neXtProt	NX_P41250
Antibodypedia	GARS antibodies

PROTEIN BROWSER

GARS-001	GARS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GARS-001 ENSP00000373918 ENST00000389266	P41250 [Direct mapping] Glycine--tRNA ligase Show all	Enzymes ENZYME proteins Ligase Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004820 [glycine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006426 [glycyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0015966 [diadenosine tetraphosphate biosynthetic process] GO:0030141 [secretory granule] GO:0030424 [axon] GO:0046983 [protein dimerization activity] GO:0070062 [extracellular exosome] Show all	739 aa 83.2 kDa	Yes	0
GARS-201 ENSP00000485931 ENST00000627489	F8WCK4 [Direct mapping] Glycine--tRNA ligase Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006426 [glycyl-tRNA aminoacylation] Show all	79 aa 8.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.