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CRHR2

GENERAL INFORMATION

Gene name

 CRHR2

Gene description

 Corticotropin releasing hormone receptor 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle)
GTEx:Tissue enhanced (pituitary gland)
FANTOM5:Tissue enhanced (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA046683
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (pituitary gland)

GENE INFORMATION

Gene name

 CRHR2 (HGNC Symbol)

Synonyms

 CRF-RB, CRF2, HM-CRF

Description

 Corticotropin releasing hormone receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

Chromosome

 7

Cytoband

 p14.3

Chromosome location (bp)

 30651943 - 30700129

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106113 (version 83.38)

Entrez gene

 1395

UniProt

 Q13324 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13324

Antibodypedia

 CRHR2 antibodies

PROTEIN BROWSER
CRHR2-001
CRHR2-002
CRHR2-006
CRHR2-201
CRHR2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRHR2-001
ENSP00000340943
ENST00000348438
Q13324 [Direct mapping]
Corticotropin-releasing factor receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005791 [rough endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007015 [actin filament organization]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0009755 [hormone-mediated signaling pathway]
GO:0009986 [cell surface]
GO:0010460 [positive regulation of heart rate]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010700 [negative regulation of norepinephrine secretion]
GO:0014064 [positive regulation of serotonin secretion]
GO:0015056 [corticotrophin-releasing factor receptor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016525 [negative regulation of angiogenesis]
GO:0017046 [peptide hormone binding]
GO:0019233 [sensory perception of pain]
GO:0021549 [cerebellum development]
GO:0021854 [hypothalamus development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030816 [positive regulation of cAMP metabolic process]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0030855 [epithelial cell differentiation]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0033685 [negative regulation of luteinizing hormone secretion]
GO:0035482 [gastric motility]
GO:0042423 [catecholamine biosynthetic process]
GO:0043025 [neuronal cell body]
GO:0043196 [varicosity]
GO:0043204 [perikaryon]
GO:0043404 [corticotropin-releasing hormone receptor activity]
GO:0043679 [axon terminus]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0043951 [negative regulation of cAMP-mediated signaling]
GO:0045777 [positive regulation of blood pressure]
GO:0046882 [negative regulation of follicle-stimulating hormone secretion]
GO:0048630 [skeletal muscle tissue growth]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060291 [long-term synaptic potentiation]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070852 [cell body fiber]
GO:0071376 [cellular response to corticotropin-releasing hormone stimulus]
GO:0071385 [cellular response to glucocorticoid stimulus]
GO:0090281 [negative regulation of calcium ion import]
GO:2000252 [negative regulation of feeding behavior]
GO:2000293 [negative regulation of defecation]
Show all
 438 aa
50.8 kDa 		Yes 7
CRHR2-002
ENSP00000418722
ENST00000471646
Q13324 [Direct mapping]
Corticotropin-releasing factor receptor 2
A0A090N7T4 [Target identity:100%; Query identity:100%]
Corticotropin releasing hormone receptor 2; Corticotropin releasing hormone receptor 2, isoform CRA_d
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 411 aa
47.7 kDa 		No 7
CRHR2-006
ENSP00000401241
ENST00000445981
C9JZM9 [Direct mapping]
Corticotropin-releasing factor receptor 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
 99 aa
11 kDa 		Yes 0
CRHR2-201
ENSP00000344304
ENST00000341843
Q13324 [Direct mapping]
Corticotropin-releasing factor receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 397 aa
46.5 kDa 		No 7
CRHR2-202
ENSP00000426498
ENST00000506074
Q13324 [Direct mapping]
Corticotropin-releasing factor receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family 2 (B) receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 387 aa
44.8 kDa 		Yes 7

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.