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Most cancer tissues showed weak to moderate cytoplasmic positivity. Colorectal cancers showed moderate to strong staining. Several squamous cell carcinomas, lymphomas, glioma and basal cell carcinomas were weakly stained or negative.
Several cases of gliomas, papillary adenocarcinomas of thyroid along with a few melanomas, hepatocellular carcinomas, endometrial and urothelial cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
PTCD1 (HGNC Symbol)
Synonyms
KIAA0632
Description
Pentatricopeptide repeat domain 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a mitochondrial protein that binds leucine tRNAs and other mitochondrial RNAs and plays a role in the regulation of translation. Increased expression of this gene results in decreased mitochondrial leucine tRNA levels. Naturally occurring read-through transcription exists between upstream ATP5J2 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2) and this gene. [provided by RefSeq, Aug 2015]