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EIF3B

GENERAL INFORMATION

Gene name

 EIF3B

Gene description

 Eukaryotic translation initiation factor 3, subunit B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA048983 , CAB017562
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable) and head and neck cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048983
CAB017562

GENE INFORMATION

Gene name

 EIF3B (HGNC Symbol)

Synonyms

 eIF3b, EIF3S9, PRT1

Description

 Eukaryotic translation initiation factor 3, subunit B (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 p22.3

Chromosome location (bp)

 2354086 - 2380745

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106263 (version 83.38)

Entrez gene

 8662

UniProt

 P55884 (UniProt - Evidence at protein level)

neXtProt

 NX_P55884

Antibodypedia

 EIF3B antibodies

PROTEIN BROWSER
EIF3B-001
EIF3B-002
EIF3B-003
EIF3B-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF3B-001
ENSP00000380206
ENST00000397011
P55884 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit B
A0A024R821 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 3 subunit B
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0001731 [formation of translation preinitiation complex]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010467 [gene expression]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0031369 [translation initiation factor binding]
GO:0032947 [protein complex scaffold]
GO:0033290 [eukaryotic 48S preinitiation complex]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
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 814 aa
92.5 kDa 		No 0
EIF3B-002
ENSP00000354125
ENST00000360876
P55884 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit B
A0A024R821 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 3 subunit B
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001731 [formation of translation preinitiation complex]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006446 [regulation of translational initiation]
GO:0010467 [gene expression]
GO:0016282 [eukaryotic 43S preinitiation complex]
GO:0031369 [translation initiation factor binding]
GO:0032947 [protein complex scaffold]
GO:0033290 [eukaryotic 48S preinitiation complex]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
GO:0071541 [eukaryotic translation initiation factor 3 complex, eIF3m]
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 814 aa
92.5 kDa 		No 0
EIF3B-003
ENSP00000407785
ENST00000413917
C9JZG1 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003743 [translation initiation factor activity]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
GO:0031369 [translation initiation factor binding]
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 302 aa
33.4 kDa 		No 0
EIF3B-008
ENSP00000408062
ENST00000431643
C9JQN7 [Direct mapping]
Eukaryotic translation initiation factor 3 subunit B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003743 [translation initiation factor activity]
GO:0005515 [protein binding]
GO:0005852 [eukaryotic translation initiation factor 3 complex]
GO:0006413 [translational initiation]
GO:0031369 [translation initiation factor binding]
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 153 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.