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Hepatocellular carcinomas and several cases of malignant gliomas, prostate, lung, renal, gastric and pancreatic cancer showed moderate to strong cytoplasmic immunoreactivity. Most other cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
WASL (HGNC Symbol)
Synonyms
N-WASP, NWASP, WASPB
Description
Wiskott-Aldrich syndrome-like (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]