Cell atlas - MOSPD3 - The Human Protein Atlas

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MOSPD3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MOSPD3
Gene description	Motile sperm domain containing 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA041137 , HPA048240
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA041137	A-431	Cytosol
HPA041137	U-251 MG	Cytosol
HPA048240	MCF7	No staining
HPA048240	PC-3	Nucleoplasm	Spatial
HPA048240	PC-3	Cytosol	Spatial
HPA048240	U-2 OS	No staining

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000037221 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048240	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	MOSPD3 (HGNC Symbol)
Synonyms	CDS3, NET30
Description	Motile sperm domain containing 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100612102 - 100615384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106330 (version 83.38)
Entrez gene	64598
UniProt	O75425 (UniProt - Evidence at transcript level)
neXtProt	NX_O75425
Antibodypedia	MOSPD3 antibodies

PROTEIN BROWSER

MOSPD3-001	MOSPD3-002	MOSPD3-003	MOSPD3-004	MOSPD3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MOSPD3-001 ENSP00000223054 ENST00000223054	O75425 [Direct mapping] Motile sperm domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	235 aa 25.5 kDa	No	2
MOSPD3-002 ENSP00000377522 ENST00000393950	O75425 [Direct mapping] Motile sperm domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0007507 [heart development] GO:0016021 [integral component of membrane] Show all	235 aa 25.5 kDa	No	2
MOSPD3-003 ENSP00000404626 ENST00000424091	O75425 [Direct mapping] Motile sperm domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	225 aa 24.4 kDa	No	2
MOSPD3-004 ENSP00000417276 ENST00000493970	C9J3M4 [Direct mapping] Motile sperm domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	226 aa 24.4 kDa	No	1
MOSPD3-201 ENSP00000368842 ENST00000379527	O75425 [Direct mapping] Motile sperm domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	235 aa 25.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.