Cell atlas - PCOLCE - The Human Protein Atlas

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PCOLCE

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	PCOLCE
Gene description	Procollagen C-endopeptidase enhancer
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Cell line enhanced (U-2197, SH-SY5Y, ASC TERT1, BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042927
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197, SH-SY5Y, ASC TERT1, BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042927	U-2 OS	Golgi apparatus	Intensity
	HPA042927	U-2 OS	Vesicles	Intensity

GENE INFORMATION
Gene name	PCOLCE (HGNC Symbol)
Synonyms	PCPE, PCPE1
Description	Procollagen C-endopeptidase enhancer (HGNC Symbol)
Entrez gene summary	Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	100602177 - 100608175
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106333 (version 83.38)
Entrez gene	5118
UniProt	Q15113 (UniProt - Evidence at protein level)
neXtProt	NX_Q15113
Antibodypedia	PCOLCE antibodies

PROTEIN BROWSER

PCOLCE-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PCOLCE-001 ENSP00000223061 ENST00000223061	Q15113 [Direct mapping] Procollagen C-endopeptidase enhancer 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0007275 [multicellular organismal development] GO:0008201 [heparin binding] GO:0010952 [positive regulation of peptidase activity] GO:0016504 [peptidase activator activity] GO:0031012 [extracellular matrix] GO:0070062 [extracellular exosome] Show all	449 aa 48 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.