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IMPDH1

GENERAL INFORMATION

Gene name

 IMPDH1

Gene description

 IMP (inosine 5'-monophosphate) dehydrogenase 1

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA001400
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), urothelial cancer (unfavourable), glioma (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Glioma p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001400

GENE INFORMATION

Gene name

 IMPDH1 (HGNC Symbol)

Synonyms

 LCA11, RP10, sWSS2608

Description

 IMP (inosine 5'-monophosphate) dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Chromosome

 7

Cytoband

 q32.1

Chromosome location (bp)

 128392277 - 128410252

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106348 (version 83.38)

Entrez gene

 3614

UniProt

 P20839 (UniProt - Evidence at protein level)

neXtProt

 NX_P20839

Antibodypedia

 IMPDH1 antibodies

PROTEIN BROWSER
IMPDH1-001
IMPDH1-002
IMPDH1-003
IMPDH1-005
IMPDH1-007
IMPDH1-008
IMPDH1-009
IMPDH1-012
IMPDH1-016
IMPDH1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IMPDH1-001
ENSP00000346219
ENST00000354269
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 589 aa
63.3 kDa 		No 0
IMPDH1-002
ENSP00000265385
ENST00000348127
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 563 aa
60.4 kDa 		No 0
IMPDH1-003
ENSP00000399400
ENST00000419067
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 566 aa
60.9 kDa 		No 0
IMPDH1-005
ENSP00000345096
ENST00000338791
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0009409 [response to cold]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046651 [lymphocyte proliferation]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0060041 [retina development in camera-type eye]
Show all
 599 aa
64.3 kDa 		No 0
IMPDH1-007
ENSP00000419609
ENST00000497868
C9K0R9 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0030054 [cell junction]
GO:0055114 [oxidation-reduction process]
Show all
 289 aa
31.2 kDa 		No 0
IMPDH1-008
ENSP00000420803
ENST00000496200
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 489 aa
52.6 kDa 		No 0
IMPDH1-009
ENSP00000420185
ENST00000480861
P20839 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0030054 [cell junction]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 509 aa
54.8 kDa 		No 0
IMPDH1-012
ENSP00000418592
ENST00000489263
C9J029 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0030054 [cell junction]
GO:0055114 [oxidation-reduction process]
Show all
 184 aa
19.5 kDa 		No 0
IMPDH1-016
ENSP00000417296
ENST00000470772
C9J381 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 513 aa
55.3 kDa 		No 0
IMPDH1-201
ENSP00000486056
ENST00000626419
C9J381 [Direct mapping]
Inosine-5'-monophosphate dehydrogenase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003938 [IMP dehydrogenase activity]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006177 [GMP biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0046872 [metal ion binding]
GO:0055114 [oxidation-reduction process]
Show all
 513 aa
55.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.