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AP1S1

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GENERAL INFORMATION

Gene name

 AP1S1

Gene description

 Adaptor-related protein complex 1, sigma 1 subunit

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported), Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA060945
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Golgi apparatus (supported), Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA060945 MCF7 Golgi apparatus
Vesicles
HPA060945 PC-3 Vesicles
HPA060945 U-2 OS Golgi apparatus
Vesicles

GENE INFORMATION

Gene name

 AP1S1 (HGNC Symbol)

Synonyms

 AP19, CLAPS1, EKV3, SIGMA1A, WUGSC:H_DJ0747G18.2

Description

 Adaptor-related protein complex 1, sigma 1 subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q22.1

Chromosome location (bp)

 101154397 - 101161596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106367 (version 83.38)

Entrez gene

 1174

UniProt

 P61966 (UniProt - Evidence at protein level)

neXtProt

 NX_P61966

Antibodypedia

 AP1S1 antibodies

PROTEIN BROWSER
AP1S1-001
AP1S1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP1S1-001
ENSP00000336666
ENST00000337619
P61966 [Direct mapping]
AP-1 complex subunit sigma-1A
A0A024QYT6 [Target identity:100%; Query identity:100%]
Adaptor-related protein complex 1, sigma 1 subunit, isoform CRA_b
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005829 [cytosol]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008565 [protein transporter activity]
GO:0009615 [response to virus]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030117 [membrane coat]
GO:0030121 [AP-1 adaptor complex]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0032588 [trans-Golgi network membrane]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043195 [terminal bouton]
GO:0050690 [regulation of defense response to virus by virus]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 158 aa
18.7 kDa 		No 0
AP1S1-004
ENSP00000399902
ENST00000429457
H7C1E4 [Direct mapping]
AP-1 complex subunit sigma-1A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 191 aa
22.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.