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C1GALT1

GENERAL INFORMATION

Gene name

 C1GALT1

Gene description

 Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA011294 , HPA012819
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and cervical cancer (unfavourable).
Liver cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011294
HPA012819

GENE INFORMATION

Gene name

 C1GALT1 (HGNC Symbol)

Synonyms

 C1GALT, T-synthase

Description

 Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.[provided by RefSeq, Sep 2010]

Chromosome

 7

Cytoband

Chromosome location (bp)

 7156934 - 7248651

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106392 (version 83.38)

Entrez gene

 56913

UniProt

 Q9NS00 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NS00

Antibodypedia

 C1GALT1 antibodies

PROTEIN BROWSER
C1GALT1-001
C1GALT1-003
C1GALT1-004
C1GALT1-006
C1GALT1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C1GALT1-001
ENSP00000223122
ENST00000223122
Q9NS00 [Direct mapping]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
A0A024RA32 [Target identity:100%; Query identity:100%]
Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001525 [angiogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016263 [glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity]
GO:0016266 [O-glycan processing]
GO:0016267 [O-glycan processing, core 1]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
Show all
 363 aa
42.2 kDa 		No 0
C1GALT1-003
ENSP00000384550
ENST00000402468
Q9NS00 [Direct mapping]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001525 [angiogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016263 [glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity]
GO:0016266 [O-glycan processing]
GO:0016267 [O-glycan processing, core 1]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
Show all
 309 aa
35.9 kDa 		No 0
C1GALT1-004
ENSP00000415400
ENST00000419721
C9JDX1 [Direct mapping]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016263 [glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity]
GO:0016266 [O-glycan processing]
Show all
 100 aa
11.3 kDa 		Yes 0
C1GALT1-006
ENSP00000407666
ENST00000429911
C9K0C8 [Direct mapping]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016263 [glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity]
GO:0016266 [O-glycan processing]
Show all
 131 aa
14.9 kDa 		Yes 0
C1GALT1-201
ENSP00000389176
ENST00000436587
Q9NS00 [Direct mapping]
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
A0A024RA32 [Target identity:100%; Query identity:100%]
Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001525 [angiogenesis]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0006493 [protein O-linked glycosylation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016263 [glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity]
GO:0016266 [O-glycan processing]
GO:0016267 [O-glycan processing, core 1]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
GO:0060576 [intestinal epithelial cell development]
Show all
 363 aa
42.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.