Expression of CLDN15 in cancer - Summary - The Human Protein Atlas

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CLDN15

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CLDN15
Gene description	Claudin 15
Protein class	Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CLDN15
Synonyms
Description	Claudin 15 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	101232092 - 101238820
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106404 (version 83.38)
Entrez gene	24146
UniProt	P56746 (UniProt - Evidence at protein level)
neXtProt	NX_P56746
Antibodypedia	CLDN15 antibodies

PROTEIN BROWSER

CLDN15-001	CLDN15-002	CLDN15-006	CLDN15-007	CLDN15-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN15-001 ENSP00000385300 ENST00000401528	P56746 [Direct mapping] Claudin-15 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005923 [bicellular tight junction] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0016328 [lateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	228 aa 24.4 kDa	No	4
CLDN15-002 ENSP00000308870 ENST00000308344	P56746 [Direct mapping] Claudin-15 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005923 [bicellular tight junction] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0034329 [cell junction assembly] GO:0042802 [identical protein binding] GO:0045216 [cell-cell junction organization] GO:0070830 [bicellular tight junction assembly] Show all	228 aa 24.4 kDa	No	4
CLDN15-006 ENSP00000398418 ENST00000414035	C9J3Z2 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	148 aa 16.1 kDa	No	3
CLDN15-007 ENSP00000390230 ENST00000412417	C9JHQ4 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	170 aa 18.1 kDa	No	3
CLDN15-201 ENSP00000481925 ENST00000611078	Q96FX9 [Direct mapping] Claudin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	128 aa 13.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.