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CEP41

GENERAL INFORMATION

Gene name

 CEP41

Gene description

 Centrosomal protein 41kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in brain and gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Caution, Splice and/or transcript discrepancy exists.

Reliability score

 Uncertain based on 1 antibody.
HPA024090
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024090

GENE INFORMATION

Gene name

 CEP41 (HGNC Symbol)

Synonyms

 DKFZp762H1311, FLJ22445, JBTS15, TSGA14

Description

 Centrosomal protein 41kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a centrosomal and microtubule-binding protein which is predicted to have two coiled-coil domains and a rhodanese domain. In human retinal pigment epithelial cells the protein localized to centrioles and cilia. Mutations in this gene have been associated with Joubert Syndrome 15; an autosomal recessive ciliopathy and neurological disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Chromosome

 7

Cytoband

 q32.2

Chromosome location (bp)

 130393771 - 130442433

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106477 (version 83.38)

Entrez gene

 95681

UniProt

 Q9BYV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYV8

Antibodypedia

 CEP41 antibodies

PROTEIN BROWSER
CEP41-001
CEP41-002
CEP41-005
CEP41-006
CEP41-010
CEP41-011
CEP41-012
CEP41-016
CEP41-201
CEP41-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEP41-001
ENSP00000223208
ENST00000223208
Q9BYV8 [Direct mapping]
Centrosomal protein of 41 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0018095 [protein polyglutamylation]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0072372 [primary cilium]
Show all
 373 aa
41.4 kDa 		No 0
CEP41-002
ENSP00000417815
ENST00000489512
Q9BYV8 [Direct mapping]
Centrosomal protein of 41 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0018095 [protein polyglutamylation]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0072372 [primary cilium]
Show all
 54 aa
6.2 kDa 		No 0
CEP41-005
ENSP00000420670
ENST00000477003
C9JCX6 [Direct mapping]
Centrosomal protein of 41 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 181 aa
20.5 kDa 		No 0
CEP41-006
ENSP00000418712
ENST00000469826
C9IZ34 [Direct mapping]
Centrosomal protein of 41 kDa
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 65 aa
7.8 kDa 		No 0
CEP41-010
ENSP00000417593
ENST00000472739
C9J9X8 [Direct mapping]
Centrosomal protein of 41 kDa
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 161 aa
17.9 kDa 		No 0
CEP41-011
ENSP00000419192
ENST00000492389
C9JXA0 [Direct mapping]
Centrosomal protein of 41 kDa
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 193 aa
21.6 kDa 		No 0
CEP41-012
ENSP00000418363
ENST00000475282
C9J6R3 [Direct mapping]
Centrosomal protein of 41 kDa
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 141 aa
15.6 kDa 		No 0
CEP41-016
ENSP00000342738
ENST00000343969
Q9BYV8 [Direct mapping]
Centrosomal protein of 41 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0018095 [protein polyglutamylation]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0072372 [primary cilium]
Show all
 301 aa
33.5 kDa 		No 0
CEP41-201
ENSP00000445888
ENST00000541543
Q9BYV8 [Direct mapping]
Centrosomal protein of 41 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0018095 [protein polyglutamylation]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0072372 [primary cilium]
Show all
 285 aa
31.6 kDa 		No 0
CEP41-202
ENSP00000479252
ENST00000616628
Q9BYV8 [Direct mapping]
Centrosomal protein of 41 kDa
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0018095 [protein polyglutamylation]
GO:0036064 [ciliary basal body]
GO:0042384 [cilium assembly]
GO:0072372 [primary cilium]
Show all
 54 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.