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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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SFRP4
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

SFRP4

Gene description

Secreted frizzled-related protein 4

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (A549, AF22, U-937)
HPA (normal tissue):Group enriched (cervix, uterine, endometrium, fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in stromal cells in both fallopian tube and endometrium as well as a subset of endometrial glandular cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Supported based on 2 antibodies.
HPA009712 , HPA050585
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA009712
HPA050585

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few colorectal, stomach, pancreas, breast, ovary and cervical cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were negative.

GENE INFORMATION

Gene name

SFRP4 (HGNC Symbol)

Synonyms

FRP-4, frpHE

Description

Secreted frizzled-related protein 4 (HGNC Symbol)

Entrez gene summary

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p14.1

Chromosome location (bp)

37905932 - 38025695

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000106483 (version 83.38)

Entrez gene

6424

UniProt

Q6FHJ7 (UniProt - Evidence at protein level)

neXtProt

NX_Q6FHJ7

Antibodypedia

SFRP4 antibodies

PROTEIN BROWSER

SFRP4-001
SFRP4-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SFRP4-001
ENSP00000410715
ENST00000436072
Q6FHJ7 [Direct mapping]
Secreted frizzled-related protein 4
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007275 [multicellular organismal development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009725 [response to hormone]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0017147 [Wnt-protein binding]
GO:0030154 [cell differentiation]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0043065 [positive regulation of apoptotic process]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045606 [positive regulation of epidermal cell differentiation]
GO:0055062 [phosphate ion homeostasis]
GO:0060070 [canonical Wnt signaling pathway]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1902174 [positive regulation of keratinocyte apoptotic process]
GO:2000119 [negative regulation of sodium-dependent phosphate transport]
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346 aa
39.8 kDa
Yes 0
SFRP4-003
ENSP00000402262
ENST00000447200
C9JMJ2 [Direct mapping]
Secreted frizzled-related protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0017147 [Wnt-protein binding]
GO:0035567 [non-canonical Wnt signaling pathway]
GO:0060070 [canonical Wnt signaling pathway]
Show all
137 aa
15.8 kDa
No 0

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