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Group enriched (cervix, uterine, endometrium, fallopian tube)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Selective cytoplasmic expression in stromal cells in both fallopian tube and endometrium as well as a subset of endometrial glandular cells.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Few colorectal, stomach, pancreas, breast, ovary and cervical cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
SFRP4 (HGNC Symbol)
Synonyms
FRP-4, frpHE
Description
Secreted frizzled-related protein 4 (HGNC Symbol)
Entrez gene summary
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]