Expression of TSPAN13 in cancer - Summary - The Human Protein Atlas

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TSPAN13

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TSPAN13
Gene description	Tetraspanin 13
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (SCLC-21H, SK-BR-3, T-47d)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA007426
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable), ovarian cancer (favourable), renal cancer (unfavourable) and liver cancer (unfavourable).
Glioma p<0.001 Ovarian cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007426

GENE INFORMATION
Gene name	TSPAN13 (HGNC Symbol)
Synonyms	NET-6, TM4SF13
Description	Tetraspanin 13 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p21.1
Chromosome location (bp)	16753535 - 16784536
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106537 (version 83.38)
Entrez gene	27075
UniProt	O95857 (UniProt - Evidence at transcript level)
neXtProt	NX_O95857
Antibodypedia	TSPAN13 antibodies

PROTEIN BROWSER

TSPAN13-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSPAN13-001 ENSP00000262067 ENST00000262067	O95857 [Direct mapping] Tetraspanin-13 Q6FGK0 [Target identity:100%; Query identity:100%] TM4SF13 protein; Tetraspanin 13, isoform CRA_a; Transmembrane 4 superfamily member 13; cDNA, FLJ95977, Homo sapiens transmembrane 4 superfamily member 13 (TM4SF13), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005246 [calcium channel regulator activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:1903169 [regulation of calcium ion transmembrane transport] Show all	204 aa 22.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.