Tissue expression of RARRES2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RARRES2
Gene description	Retinoic acid receptor responder (tazarotene induced) 2
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adrenal gland)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RARRES2 (HGNC Symbol)
Synonyms	HP10433, TIG2
Description	Retinoic acid receptor responder (tazarotene induced) 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted chemotactic protein that initiates chemotaxis via the ChemR23 G protein-coupled seven-transmembrane domain ligand. Expression of this gene is upregulated by the synthetic retinoid tazarotene and occurs in a wide variety of tissues. The active protein has several roles, including that as an adipokine and as an antimicrobial protein with activity against bacteria and fungi. [provided by RefSeq, Nov 2014]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	150338317 - 150341674
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106538 (version 83.38)
Entrez gene	5919
UniProt	Q99969 (UniProt - Evidence at protein level)
neXtProt	NX_Q99969
Antibodypedia	RARRES2 antibodies

PROTEIN BROWSER

RARRES2-001	RARRES2-002	RARRES2-003	RARRES2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RARRES2-001 ENSP00000223271 ENST00000223271	Q99969 [Direct mapping] Retinoic acid receptor responder protein 2 A0A090N7U9 [Target identity:100%; Query identity:100%] Retinoic acid receptor responder (Tazarotene induced) 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001701 [in utero embryonic development] GO:0001934 [positive regulation of protein phosphorylation] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0030154 [cell differentiation] GO:0031012 [extracellular matrix] GO:0045600 [positive regulation of fat cell differentiation] GO:0048566 [embryonic digestive tract development] GO:0050921 [positive regulation of chemotaxis] GO:0050994 [regulation of lipid catabolic process] GO:0070062 [extracellular exosome] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	163 aa 18.6 kDa	Yes	0
RARRES2-002 ENSP00000418483 ENST00000482669	Q99969 [Direct mapping] Retinoic acid receptor responder protein 2 A0A090N7U9 [Target identity:100%; Query identity:100%] Retinoic acid receptor responder (Tazarotene induced) 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001701 [in utero embryonic development] GO:0001934 [positive regulation of protein phosphorylation] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0030154 [cell differentiation] GO:0031012 [extracellular matrix] GO:0045600 [positive regulation of fat cell differentiation] GO:0048566 [embryonic digestive tract development] GO:0050921 [positive regulation of chemotaxis] GO:0050994 [regulation of lipid catabolic process] GO:0070062 [extracellular exosome] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	163 aa 18.6 kDa	Yes	0
RARRES2-003 ENSP00000418009 ENST00000466675	Q99969 [Direct mapping] Retinoic acid receptor responder protein 2 A0A090N7U9 [Target identity:100%; Query identity:100%] Retinoic acid receptor responder (Tazarotene induced) 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0001701 [in utero embryonic development] GO:0001934 [positive regulation of protein phosphorylation] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006935 [chemotaxis] GO:0006954 [inflammatory response] GO:0010759 [positive regulation of macrophage chemotaxis] GO:0030154 [cell differentiation] GO:0031012 [extracellular matrix] GO:0045600 [positive regulation of fat cell differentiation] GO:0048566 [embryonic digestive tract development] GO:0050921 [positive regulation of chemotaxis] GO:0050994 [regulation of lipid catabolic process] GO:0070062 [extracellular exosome] GO:2001275 [positive regulation of glucose import in response to insulin stimulus] Show all	163 aa 18.6 kDa	Yes	0
RARRES2-005 ENSP00000417669 ENST00000467793	C9J8S2 [Direct mapping] Retinoic acid receptor responder protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0006954 [inflammatory response] GO:0050994 [regulation of lipid catabolic process] Show all	159 aa 17.8 kDa	Yes	0