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AHR

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GENERAL INFORMATION

Gene name

 AHR

Gene description

 Aryl hydrocarbon receptor

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol & nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated), Cytosol (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB005072 , HPA029722
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (validated), Cytosol (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029722 A-431 Nucleoplasm
HPA029722 U-251 MG Nucleoplasm
Cytosol
CAB005072 A-431 Cytosol
CAB005072 U-2 OS Cytosol
CAB005072 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 AHR (HGNC Symbol)

Synonyms

 bHLHe76

Description

 Aryl hydrocarbon receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015]

Chromosome

 7

Cytoband

 p21.1

Chromosome location (bp)

 17298622 - 17346152

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106546 (version 83.38)

Entrez gene

 196

UniProt

 P35869 (UniProt - Evidence at protein level)

neXtProt

 NX_P35869

Antibodypedia

 AHR antibodies

PROTEIN BROWSER
AHR-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AHR-002
ENSP00000242057
ENST00000242057
P35869 [Direct mapping]
Aryl hydrocarbon receptor
A0A024R9Z8 [Target identity:100%; Query identity:100%]
Aryl hydrocarbon receptor, isoform CRA_a
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001541 [ovarian follicle development]
GO:0001568 [blood vessel development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006805 [xenobiotic metabolic process]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0009410 [response to xenobiotic stimulus]
GO:0009636 [response to toxic substance]
GO:0010468 [regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0030522 [intracellular receptor signaling pathway]
GO:0030850 [prostate gland development]
GO:0030888 [regulation of B cell proliferation]
GO:0032355 [response to estradiol]
GO:0032922 [circadian regulation of gene expression]
GO:0034752 [cytosolic aryl hydrocarbon receptor complex]
GO:0034753 [nuclear aryl hydrocarbon receptor complex]
GO:0035326 [enhancer binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045899 [positive regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0046983 [protein dimerization activity]
GO:0048608 [reproductive structure development]
GO:0048732 [gland development]
GO:0051879 [Hsp90 protein binding]
GO:0070888 [E-box binding]
GO:0071385 [cellular response to glucocorticoid stimulus]
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 848 aa
96.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.