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BLVRA

GENERAL INFORMATION

Gene name

 BLVRA

Gene description

 Biliverdin reductase A

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including lymphocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA042865 , HPA054322
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042865
HPA054322

GENE INFORMATION

Gene name

 BLVRA (HGNC Symbol)

Synonyms

 BLVR

Description

 Biliverdin reductase A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 43758680 - 43807342

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106605 (version 83.38)

Entrez gene

 644

UniProt

 P53004 (UniProt - Evidence at protein level)

neXtProt

 NX_P53004

Antibodypedia

 BLVRA antibodies

PROTEIN BROWSER
BLVRA-001
BLVRA-002
BLVRA-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BLVRA-001
ENSP00000265523
ENST00000265523
P53004 [Direct mapping]
Biliverdin reductase A
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004074 [biliverdin reductase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0042167 [heme catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 296 aa
33.4 kDa 		No 0
BLVRA-002
ENSP00000385757
ENST00000402924
P53004 [Direct mapping]
Biliverdin reductase A
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004074 [biliverdin reductase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0008270 [zinc ion binding]
GO:0016491 [oxidoreductase activity]
GO:0042167 [heme catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 296 aa
33.4 kDa 		No 0
BLVRA-003
ENSP00000412005
ENST00000424330
C9J1E1 [Direct mapping]
Biliverdin reductase A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 102 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.