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RHEB

GENERAL INFORMATION

Gene name

 RHEB

Gene description

 Ras homolog enriched in brain

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB019436
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 RHEB (HGNC Symbol)

Synonyms

 RHEB2

Description

 Ras homolog enriched in brain (HGNC Symbol)

Entrez gene summary

 This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 151466012 - 151520120

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106615 (version 83.38)

Entrez gene

 6009

UniProt

 Q15382 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15382

Antibodypedia

 RHEB antibodies

PROTEIN BROWSER
RHEB-001
RHEB-002
RHEB-003
RHEB-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RHEB-001
ENSP00000262187
ENST00000262187
Q15382 [Direct mapping]
GTP-binding protein Rheb
A0A090N900 [Target identity:100%; Query identity:100%]
Ras homolog enriched in brain; Ras homolog enriched in brain, isoform CRA_c
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005681 [spliceosomal complex]
GO:0005765 [lysosomal membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008286 [insulin receptor signaling pathway]
GO:0010467 [gene expression]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019901 [protein kinase binding]
GO:0032006 [regulation of TOR signaling]
GO:0032008 [positive regulation of TOR signaling]
GO:0046872 [metal ion binding]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0070062 [extracellular exosome]
GO:2000074 [regulation of type B pancreatic cell development]
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 184 aa
20.5 kDa 		No 0
RHEB-002
ENSP00000418161
ENST00000496004
C9J931 [Direct mapping]
GTP-binding protein Rheb
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 79 aa
8.7 kDa 		No 0
RHEB-003
ENSP00000420726
ENST00000472642
C9J931 [Direct mapping]
GTP-binding protein Rheb
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0016020 [membrane]
Show all
 79 aa
8.7 kDa 		No 0
RHEB-007
ENSP00000417212
ENST00000470370
C9J469 [Direct mapping]
GTP-binding protein Rheb
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 19 aa
2.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.