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GCK

GENERAL INFORMATION

Gene name

 GCK

Gene description

 Glucokinase (hexokinase 4)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Cell line enriched (SCLC-21H)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA007034 , HPA007093
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007034
HPA007093

GENE INFORMATION

Gene name

 GCK (HGNC Symbol)

Synonyms

 HK4, MODY2

Description

 Glucokinase (hexokinase 4) (HGNC Symbol)

Entrez gene summary

 Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

Chromosome

 7

Cytoband

 p13

Chromosome location (bp)

 44144271 - 44198170

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106633 (version 83.38)

Entrez gene

 2645

UniProt

 P35557 (UniProt - Evidence at protein level)

neXtProt

 NX_P35557

Antibodypedia

 GCK antibodies

PROTEIN BROWSER
GCK-001
GCK-002
GCK-003
GCK-004
GCK-006
GCK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCK-001
ENSP00000384247
ENST00000403799
P35557 [Direct mapping]
Glucokinase
Q53Y25 [Target identity:100%; Query identity:100%]
Hexokinase
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0008645 [hexose transport]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0050796 [regulation of insulin secretion]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
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 465 aa
52.2 kDa 		No 0
GCK-002
ENSP00000223366
ENST00000345378
P35557 [Direct mapping]
Glucokinase
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005938 [cell cortex]
GO:0005975 [carbohydrate metabolic process]
GO:0005978 [glycogen biosynthetic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0006739 [NADP metabolic process]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008645 [hexose transport]
GO:0009749 [response to glucose]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0019903 [protein phosphatase binding]
GO:0019932 [second-messenger-mediated signaling]
GO:0030141 [secretory granule]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032811 [negative regulation of epinephrine secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042149 [cellular response to glucose starvation]
GO:0042327 [positive regulation of phosphorylation]
GO:0042593 [glucose homeostasis]
GO:0043266 [regulation of potassium ion transport]
GO:0043531 [ADP binding]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045180 [basal cortex]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0050796 [regulation of insulin secretion]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061621 [canonical glycolysis]
GO:0070509 [calcium ion import]
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 466 aa
52.1 kDa 		No 0
GCK-003
ENSP00000379142
ENST00000395796
P35557 [Direct mapping]
Glucokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0008645 [hexose transport]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0050796 [regulation of insulin secretion]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
Show all
 464 aa
52 kDa 		No 0
GCK-004
ENSP00000402840
ENST00000437084
C9JQD1 [Direct mapping]
Hexokinase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004396 [hexokinase activity]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0046835 [carbohydrate phosphorylation]
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 448 aa
50.1 kDa 		No 0
GCK-006
ENSP00000338009
ENST00000336642
H7BXV0 [Direct mapping]
Glucokinase
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Predicted intracellular proteins
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006096 [glycolytic process]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0046835 [carbohydrate phosphorylation]
Show all
 149 aa
15.9 kDa 		No 0
GCK-201
ENSP00000482149
ENST00000616242
P35557 [Direct mapping]
Glucokinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0001678 [cellular glucose homeostasis]
GO:0004340 [glucokinase activity]
GO:0004396 [hexokinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005536 [glucose binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0006110 [regulation of glycolytic process]
GO:0008645 [hexose transport]
GO:0010827 [regulation of glucose transport]
GO:0015758 [glucose transport]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0031018 [endocrine pancreas development]
GO:0032024 [positive regulation of insulin secretion]
GO:0032869 [cellular response to insulin stimulus]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044320 [cellular response to leptin stimulus]
GO:0045721 [negative regulation of gluconeogenesis]
GO:0045725 [positive regulation of glycogen biosynthetic process]
GO:0050796 [regulation of insulin secretion]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0051594 [detection of glucose]
GO:0055085 [transmembrane transport]
GO:0061621 [canonical glycolysis]
Show all
 464 aa
52 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.