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LIMK1

GENERAL INFORMATION

Gene name

 LIMK1

Gene description

 LIM domain kinase 1

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA028064 , HPA028516
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
HPA028064
HPA028516

GENE INFORMATION

Gene name

 LIMK1 (HGNC Symbol)

Synonyms

 LIMK

Description

 LIM domain kinase 1 (HGNC Symbol)

Entrez gene summary

 There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 74082933 - 74122525

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106683 (version 83.38)

Entrez gene

 3984

UniProt

 P53667 (UniProt - Evidence at protein level)

neXtProt

 NX_P53667

Antibodypedia

 LIMK1 antibodies

PROTEIN BROWSER
LIMK1-001
LIMK1-002
LIMK1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIMK1-001
ENSP00000336740
ENST00000336180
P53667 [Direct mapping]
LIM domain kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0031072 [heat shock protein binding]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0044295 [axonal growth cone]
GO:0045087 [innate immune response]
GO:0045773 [positive regulation of axon extension]
GO:0046982 [protein heterodimerization activity]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051496 [positive regulation of stress fiber assembly]
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 647 aa
72.6 kDa 		No 0
LIMK1-002
ENSP00000409717
ENST00000418310
E9PC47 [Direct mapping]
LIM domain kinase 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008270 [zinc ion binding]
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 677 aa
75.5 kDa 		No 0
LIMK1-005
ENSP00000444452
ENST00000538333
P53667 [Direct mapping]
LIM domain kinase 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008270 [zinc ion binding]
GO:0030036 [actin cytoskeleton organization]
GO:0031072 [heat shock protein binding]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0045087 [innate immune response]
GO:0045773 [positive regulation of axon extension]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
Show all
 613 aa
68.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.