Fields »
ABOUT
HELP
BLOG
LHX2

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 LHX2

Gene description

 LIM homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (NTERA-2, AN3-CA)

Protein evidence

 Evidence at transcript level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA000838
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (NTERA-2, AN3-CA)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA000838 HeLa Nucleoplasm
HPA000838 MCF7 Nucleoplasm
HPA000838 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 LHX2 (HGNC Symbol)

Synonyms

 hLhx2, LH-2

Description

 LIM homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q33.3

Chromosome location (bp)

 124001670 - 124033301

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000106689 (version 83.38)

Entrez gene

 9355

UniProt

 P50458 (UniProt - Evidence at transcript level)

neXtProt

 NX_P50458

Antibodypedia

 LHX2 antibodies

PROTEIN BROWSER
LHX2-001
LHX2-002
LHX2-003
LHX2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LHX2-001
ENSP00000362717
ENST00000373615
P50458 [Direct mapping]
LIM/homeobox protein Lhx2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0001076 [transcription factor activity, RNA polymerase II transcription factor binding]
GO:0001843 [neural tube closure]
GO:0001942 [hair follicle development]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007420 [brain development]
GO:0007498 [mesoderm development]
GO:0008270 [zinc ion binding]
GO:0009953 [dorsal/ventral pattern formation]
GO:0021537 [telencephalon development]
GO:0021772 [olfactory bulb development]
GO:0021978 [telencephalon regionalization]
GO:0021987 [cerebral cortex development]
GO:0022008 [neurogenesis]
GO:0030182 [neuron differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045199 [maintenance of epithelial cell apical/basal polarity]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048675 [axon extension]
GO:0060041 [retina development in camera-type eye]
GO:2000678 [negative regulation of transcription regulatory region DNA binding]
Show all
 406 aa
44.4 kDa 		No 0
LHX2-002
ENSP00000394978
ENST00000446480
H7C0H1 [Direct mapping]
LIM/homeobox protein Lhx2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 412 aa
44.8 kDa 		No 0
LHX2-003
ENSP00000476200
ENST00000488674
U3KQT5 [Direct mapping]
LIM/homeobox protein Lhx2
Show all
Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
Show all
 115 aa
12.5 kDa 		No 0
LHX2-004
ENSP00000453448
ENST00000560961
H0YM35 [Direct mapping]
LIM/homeobox protein Lhx2
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
Show all
 147 aa
16.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.