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Most cancer tissues displayed weak to moderate cytoplasmic staining. Testicular, skin, lung and cervical cancers along with lymphomas were mainly negative
GENE INFORMATION
Gene name
FKTN (HGNC Symbol)
Synonyms
FCMD, LGMD2M
Description
Fukutin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a putative transmembrane protein that is localized to the cis-Golgi compartment, where it may be involved in the glycosylation of alpha-dystroglycan in skeletal muscle. The encoded protein is thought to be a glycosyltransferase and could play a role in brain development. Defects in this gene are a cause of Fukuyama-type congenital muscular dystrophy (FCMD), Walker-Warburg syndrome (WWS), limb-girdle muscular dystrophy type 2M (LGMD2M), and dilated cardiomyopathy type 1X (CMD1X). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2010]