Expression of CNTNAP3 in cancer - Summary - The Human Protein Atlas

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CNTNAP3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CNTNAP3
Gene description	Contactin associated protein-like 3
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, AF22, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Limited external characterization data supports antibody staining.
Reliability score	Approved based on 2 antibodies. HPA015604 , HPA047731
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015604	HPA047731

GENE INFORMATION
Gene name	CNTNAP3 (HGNC Symbol)
Synonyms	CASPR3, CNTNAP3A, FLJ14195, KIAA1714
Description	Contactin associated protein-like 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the NCP family of cell-recognition molecules. This family represents a distinct subgroup of the neurexins. NCP proteins mediate neuron-glial interactions in vertebrates and glial-glial contact in invertebrates. The protein encoded by this gene may play a role in cell recognition within the nervous system. Alternatively spliced transcript variants encoding different isoforms have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p12
Chromosome location (bp)	39072767 - 39288315
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000106714 (version 83.38)
Entrez gene	79937
UniProt	Q9BZ76 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BZ76
Antibodypedia	CNTNAP3 antibodies

PROTEIN BROWSER

CNTNAP3-001	CNTNAP3-003	CNTNAP3-006	CNTNAP3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTNAP3-001 ENSP00000297668 ENST00000297668	Q9BZ76 [Direct mapping] Contactin-associated protein-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0008037 [cell recognition] GO:0016021 [integral component of membrane] Show all	1288 aa 140.7 kDa	Yes	1
CNTNAP3-003 ENSP00000350863 ENST00000358144	B1AMA2 [Direct mapping] Contactin-associated protein-like 3 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1039 aa 114.8 kDa	No	0
CNTNAP3-006 ENSP00000366887 ENST00000377659	B1AM99 [Direct mapping] Contactin-associated protein-like 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	745 aa 81.6 kDa	Yes	0
CNTNAP3-201 ENSP00000366884 ENST00000377656	A6NC89 [Direct mapping] Contactin-associated protein-like 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1207 aa 132.2 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.