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SPIN1

GENERAL INFORMATION

Gene name

 SPIN1

Gene description

 Spindlin 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA000162
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000162

GENE INFORMATION

Gene name

 SPIN1 (HGNC Symbol)

Synonyms

 SPIN, TDRD24

Description

 Spindlin 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q22.1

Chromosome location (bp)

 88388419 - 88478694

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106723 (version 83.38)

Entrez gene

 10927

UniProt

 Q9Y657 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y657

Antibodypedia

 SPIN1 antibodies

PROTEIN BROWSER
SPIN1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPIN1-001
ENSP00000365019
ENST00000375859
Q9Y657 [Direct mapping]
Spindlin-1
A0A024R297 [Target identity:100%; Query identity:100%]
Spindlin, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005819 [spindle]
GO:0007275 [multicellular organismal development]
GO:0007276 [gamete generation]
GO:0009303 [rRNA transcription]
GO:0016055 [Wnt signaling pathway]
GO:0016568 [chromatin modification]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0035064 [methylated histone binding]
GO:0051321 [meiotic cell cycle]
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 262 aa
29.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.