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Most cancer tissues displayed weak to moderate cytoplasmic staining with additional membranous positivity in several cases. Malignant gliomas, lymphomas, melanomas, testicular and renal cancers were mainly negative.
GENE INFORMATION
Gene name
NMRK1 (HGNC Symbol)
Synonyms
bA235O14.2, C9orf95, FLJ20559, NRK1
Description
Nicotinamide riboside kinase 1 (HGNC Symbol)
Entrez gene summary
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]