Expression of TMEM245 in cancer - Summary - The Human Protein Atlas

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TMEM245

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM245
Gene description	Transmembrane protein 245
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA023892
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023892

GENE INFORMATION
Gene name	TMEM245 (HGNC Symbol)
Synonyms	C9orf5, CG-2
Description	Transmembrane protein 245 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband	q31.3
Chromosome location (bp)	109015152 - 109119945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106771 (version 83.38)
Entrez gene	23731
UniProt	Q9H330 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H330
Antibodypedia	TMEM245 antibodies

PROTEIN BROWSER

TMEM245-001	TMEM245-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM245-001 ENSP00000363714 ENST00000374586	Q9H330 [Direct mapping] Transmembrane protein 245 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	879 aa 97.4 kDa	No	>9
TMEM245-006 ENSP00000394798 ENST00000413712	H7C0G1 [Direct mapping] Transmembrane protein 245 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	472 aa 52.7 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.