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Cancer tissues showed weak to moderate cytoplasmic and nuclear staining. Occasional cases of urothelial cancers displayed strong positivity.
GENE INFORMATION
Gene name
SEC61B
Synonyms
Description
Sec61 translocon beta subunit (HGNC Symbol)
Entrez gene summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]