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OGN

GENERAL INFORMATION

Gene name

 OGN

Gene description

 Osteoglycin

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (ASC TERT1, MOLT-4)
HPA (normal tissue):Tissue enhanced (cervix, uterine, parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in smooth muscle and staining in extracellular matrix in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Approved based on 1 antibody.
HPA013132
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013132

GENE INFORMATION

Gene name

 OGN (HGNC Symbol)

Synonyms

 mimecan, OIF, SLRR3A

Description

 Osteoglycin (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.31

Chromosome location (bp)

 92383967 - 92404696

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000106809 (version 83.38)

Entrez gene

 4969

UniProt

 P20774 (UniProt - Evidence at protein level)

neXtProt

 NX_P20774

Antibodypedia

 OGN antibodies

PROTEIN BROWSER
OGN-001
OGN-002
OGN-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OGN-001
ENSP00000364711
ENST00000375561
P20774 [Direct mapping]
Mimecan
A8K0R3 [Target identity:100%; Query identity:100%]
Osteoglycin (Osteoinductive factor, mimecan), isoform CRA_a; cDNA FLJ78199, highly similar to Homo sapiens osteoglycin (osteoinductive factor, mimecan) (OGN), transcript variant 3, mRNA; cDNA PSEC0219 fis, clone HEMBA1005229, highly similar to Mimecan
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0031012 [extracellular matrix]
GO:0042339 [keratan sulfate metabolic process]
GO:0042340 [keratan sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
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 298 aa
33.9 kDa 		Yes 0
OGN-002
ENSP00000262551
ENST00000262551
P20774 [Direct mapping]
Mimecan
A8K0R3 [Target identity:100%; Query identity:100%]
Osteoglycin (Osteoinductive factor, mimecan), isoform CRA_a; cDNA FLJ78199, highly similar to Homo sapiens osteoglycin (osteoinductive factor, mimecan) (OGN), transcript variant 3, mRNA; cDNA PSEC0219 fis, clone HEMBA1005229, highly similar to Mimecan
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0018146 [keratan sulfate biosynthetic process]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0031012 [extracellular matrix]
GO:0042339 [keratan sulfate metabolic process]
GO:0042340 [keratan sulfate catabolic process]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
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 298 aa
33.9 kDa 		Yes 0
OGN-003
ENSP00000396709
ENST00000447356
Q5TBF5 [Direct mapping]
Mimecan
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 268 aa
30.5 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.