Expression of ECM2 in cancer - Summary - The Human Protein Atlas

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ECM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ECM2
Gene description	Extracellular matrix protein 2, female organ and adipocyte specific
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (ASC TERT1, hTCEpi)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, high levels in adipocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA035347
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035347

GENE INFORMATION
Gene name	ECM2
Synonyms
Description	Extracellular matrix protein 2, female organ and adipocyte specific (HGNC Symbol)
Entrez gene summary	ECM2 encodes extracellular matrix protein 2, so named because it shares extensive similarity with known extracelluar matrix proteins. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	92493554 - 92536655
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000106823 (version 83.38)
Entrez gene	1842
UniProt	O94769 (UniProt - Evidence at transcript level)
neXtProt	NX_O94769
Antibodypedia	ECM2 antibodies

PROTEIN BROWSER

ECM2-001	ECM2-002	ECM2-003	ECM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECM2-001 ENSP00000344758 ENST00000344604	O94769 [Direct mapping] Extracellular matrix protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005614 [interstitial matrix] GO:0005615 [extracellular space] GO:0007160 [cell-matrix adhesion] GO:0007409 [axonogenesis] GO:0008201 [heparin binding] GO:0010811 [positive regulation of cell-substrate adhesion] GO:0030198 [extracellular matrix organization] GO:0070052 [collagen V binding] Show all	699 aa 79.8 kDa	Yes	0
ECM2-002 ENSP00000364690 ENST00000375540	Q5T9F3 [Direct mapping] Extracellular matrix protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	164 aa 18.7 kDa	Yes	0
ECM2-003 ENSP00000378905 ENST00000395534	Q5T9F4 [Direct mapping] Extracellular matrix protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	160 aa 18.3 kDa	Yes	0
ECM2-201 ENSP00000393971 ENST00000444490	O94769 [Direct mapping] Extracellular matrix protein 2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007160 [cell-matrix adhesion] GO:0007409 [axonogenesis] GO:0008201 [heparin binding] GO:0070052 [collagen V binding] Show all	643 aa 73.3 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.